Zopiclone impurity-1

Name: Zopiclone impurity-1
Brand: ChemScene
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CAS No. 43200-81-3
Cat. No. CS-0156767
Purity≥98%
MDL No.MFCD02684321

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 43200-81-3
Cat. No. CS-0156767
Purity ≥98%
MDL No. MFCD02684321
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₇ClN₄O₂
Molecular Weight 262.66
Synonym(s) RP 29307
SMILES C1=CC(=NC=C1Cl)N2C(C3=C(C2=O)N=CC=N3)O

Description

Hmb protection of amide bonds has been shown to inhibit aggregation of "difficult" peptides by Fmoc SPPS, thereby leading to products of increased purity [1,2,3,4,5,6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7, 8] and otherwise intractable sequences [9,10,11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxyl group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12,13,14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15]. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPSLiterature references[1] T. Johnson, et al. (1993) J. Chem. Soc., Chem. Commun., 369. [2] C. Hyde, et al. (1994) Int. J. Peptide Protein Res., 43, 431. [3] L. C. Packman, et al. (1994) Pept. Res., 7, 125. [4] T. Johnson, et al. (1994) Tetrahedron Lett., 35, 463. [5] R. G. Simmonds (1996) Int. J. Peptide Protein Res., 47, 36. [6] T. Johnson, et al. (1995) Lett. Pept. Sci., 1, 11. [7] M. Quibell, et al. (1995) J. Am. Chem. Soc., 117, 11656. [8] M. Quibell, et al. (1996) J. Chem. Soc., Perkin Trans. 1, 1227. [9] M. Quibell, et al. (1994) Tetrahedron Lett., 35, 2237. [10] M. Quibell, et al. (1994) J. Org. Chem., 59, 1745. [11] M. Quibell, et al. (1995) J. Chem. Soc., Perkin Trans. 1, 2019. [12] M. Quibell, et al. (1994) J. Chem. Soc., Chem. Commun., 2343. [13] L. C. Packman (1995) Tetrahedron Lett., 36, 7523. [14] J. Offer, et al. (1996) J. Chem. Soc., Perkin Trans. 1, 175. [15] W. R. Sampson, et al. (1999) J. Peptide Sci., 5, 403.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 79.21
LogP 1.1763
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

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Zopiclone impurity-1

CAS No. 43200-81-3

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