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1-(Thiazol-2-yl)propan-1-one

  • CAS No. 43039-98-1

  • Cat. No. CS-0152648
  • Molecule weight141.19
  • Purity≥98%
  • MDL No.MFCD01681404

*For research and further manufacturing use only, not for direct human use.

1-(Thiazol-2-yl)propan-1-one|CS-0152648

Structure of 43039-98-1

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General Information

  • CAS No. 43039-98-1
  • Cat. No. CS-0152648
  • Purity ≥98%
  • MDL No. MFCD01681404
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NOS
  • Molecular Weight 141.19
  • Synonym(s) 2-Propionylthiazole
  • SMILES CCC(=O)C1=NC=CS1

Description

1-(Thiazol-2-yl)propan-1-one features a thiazole ring fused to a reactive ketone moiety, enabling direct incorporation into heterocyclic scaffolds. This bench-stable compound serves as a key synthon in medicinal chemistry, facilitating efficient access to thiazole-based bioactive molecules through nucleophilic addition and condensation reactions.

Application

1-(Thiazol-2-yl)propan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of thiazole-containing scaffolds via nucleophilic addition and condensation reactions. Its α-keto functionality facilitates facile transformations with amines, hydrazines, and other nucleophiles, while the thiazole ring provides enhanced metabolic stability and favorable pharmacophoric properties. The compound exhibits good bench stability and is amenable to purification by standard chromatographic techniques, supporting its use in multi-step syntheses of bioactive molecules.

Synthesis

  • Route1
    • null|null
      112969-95-6
    • ~65%
    • In-stock
      1-(Thiazol-2-yl)propan-1-one|CS-0152648
      43039-98-1

    References

    • Wang, Xinbo; Wang, David Zhigang Tetrahedron, 2011 , vol. 67, # 19 p. 3406 - 3411
  • Route2

    References

    • Bird; Bruneau; Crawley; Edwards; Foster; Girodeau; Kingston; McMillan Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2176 - 2186
  • Route3
    • 1-(Thiazol-2-yl)propan-1-ol|CS-0295812
      89464-29-9
    • ~%
    • In-stock
      1-(Thiazol-2-yl)propan-1-one|CS-0152648
      43039-98-1

    References

    • Beraud,J.; Metzger,J. Bulletin de la Societe Chimique de France, 1962 , p. 2072 - 2074

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.7358
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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