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CS-W001157 4
Total: USD 88.00

Furan-2,4-dicarboxylic acid

  • CAS No. 4282-28-4

  • Cat. No. CS-0309016
  • Purity≥95%
  • MDL No.MFCD00159521

*For research and further manufacturing use only, not for direct human use.

Furan-2,4-dicarboxylic acid|CS-0309016

Structure of 4282-28-4

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General Information

  • CAS No. 4282-28-4
  • Cat. No. CS-0309016
  • Purity ≥95%
  • MDL No. MFCD00159521
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄O₅
  • Molecular Weight 156.09
  • Synonym(s) 2,4-Furandicarboxylic acid
  • SMILES O=C(O)C=1OC=C(C1)C(=O)O

Description

Furan-2,4-dicarboxylic acid features a conjugated furan ring flanked by two carboxylic acid groups, enabling strong coordination in metal-organic frameworks. This electron-deficient heterocycle integrates readily into functional materials requiring thermal stability and defined polarity. The molecule's planar geometry supports π-stacking interactions in crystalline assemblies.

Application

Furan-2,4-dicarboxylic acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its two carboxylic acid groups facilitate straightforward derivatization via esterification, amide formation, or coupling reactions, while the electron-rich furan core supports electrophilic substitution and transition-metal-catalyzed cross-couplings. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for scalable synthesis and process development.

Synthesis

  • Route1
    • Potassium furan-2-carboxylate|CS-0657783
      20842-02-8
    • ~0%
    • null|null
      110-00-9
    • 2,5-Furandicarboxylic acid,99.99%|CS-1709659
      3238-40-2
    • In-stock
      Furan-2,4-dicarboxylic acid|CS-0309016
      4282-28-4

    References

    • Thiyagarajan, Shanmugam; Pukin, Aliaksei; Van Haveren, Jacco; Lutz, Martin; Van Es, Daan S. RSC Advances, 2013 , vol. 3, # 36 p. 15678 - 15686
  • Route2
    • null|null
      32365-55-2
    • ~%
    • In-stock
      Furan-2,4-dicarboxylic acid|CS-0309016
      4282-28-4

    References

    • Jones Journal of the American Chemical Society, 1955 , vol. 77, p. 4069,4072
  • Route3
    • Vanillin, ≥97%|CS-1268660
      121-33-5
    • ~%
    • In-stock
      Furan-2,4-dicarboxylic acid|CS-0309016
      4282-28-4

    References

    • Pearl; Barton Journal of the American Chemical Society, 1952 , vol. 74, p. 1357

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   87.74
  • LogP   0.676
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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