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CS-W001157 4
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2,2-Difluoropropane-1,3-diol

  • CAS No. 428-63-7

  • Cat. No. CS-0094694
  • Purity≥95%
  • MDL No.MFCD16619633

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoropropane-1,3-diol|CS-0094694

Structure of 428-63-7

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General Information

  • CAS No. 428-63-7
  • Cat. No. CS-0094694
  • Purity ≥95%
  • MDL No. MFCD16619633
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₆F₂O₂
  • Molecular Weight 112.08
  • Synonym(s) 2,2-Difluoro-1,3-dihydroxypropane
  • SMILES OCC(F)(F)CO

Description

The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.

Application

2,2-Difluoropropane-1,3-diol serves as a stable, bench-ready building block for fluorinated diol architectures. Its difluoromethylene group imparts enhanced metabolic stability and modulates polarity, enabling utility in the synthesis of bioactive molecules and fluorinated heterocycles. The molecule functions effectively in standard coupling and protection protocols, with tolerance to diverse reaction conditions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.3937
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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