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CS-W001157 4
Total: USD 88.00

D-Valinol

  • CAS No. 4276-09-9

  • Cat. No. CS-D0610
  • Purity≥97%
  • MDL No.MFCD00064297

*For research and further manufacturing use only, not for direct human use.

D-Valinol|CS-D0610

Structure of 4276-09-9

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General Information

  • CAS No. 4276-09-9
  • Cat. No. CS-D0610
  • Purity ≥97%
  • MDL No. MFCD00064297
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₃NO
  • Molecular Weight 103.16
  • Synonym(s) (R)-2-Amino-3-methyl-butanol
  • SMILES N[C@@H](CO)C(C)C

Description

D-Valinol features a chiral tertiary alcohol structure derived from D-valine, offering enhanced stability and predictable stereochemical behavior. This bench-stable derivative integrates readily into peptide mimetics and kinase inhibitor scaffolds, serving as a key building block in asymmetric synthesis workflows.

Application

D-Valinol serves as a valuable chiral building block in peptide synthesis and medicinal chemistry, offering a stable, bench-ready amino alcohol with high functional group tolerance. Its secondary hydroxyl and primary amine groups enable straightforward derivatization for protected intermediates, while its D-configuration provides stereochemical control in the construction of bioactive heterocycles and peptidomimetics.

Synthesis

  • Route1

    References

    • Quagliato, Dominick A.; Andrae, Patrick M.; Matelan, Edward M. Journal of Organic Chemistry, 2000 , vol. 65, # 16 p. 5037 - 5042
  • Route2
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      D-Valinol|CS-D0610
      4276-09-9

    References

    • US4479005 A1, ;
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      D-Valinol|CS-D0610
      4276-09-9

    References

    • Journal of the Chemical Society, , p. 3965 - 3972

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.038
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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