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CS-W001157 4
Total: USD 88.00

2-Aminoquinolin-4-ol

  • CAS No. 42712-64-1

  • Cat. No. CS-W016163
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD00052386

*For research and further manufacturing use only, not for direct human use.

2-Aminoquinolin-4-ol|CS-W016163

Structure of 42712-64-1

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General Information

  • CAS No. 42712-64-1
  • Cat. No. CS-W016163
  • Purity ≥95%
  • MDL No. MFCD00052386
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight None
  • Synonym(s) 4-Quinolinol, 2-amino-
  • SMILES OC1=CC(N)=NC2=CC=CC=C12

Description

2-Aminoquinolin-4-ol features a fused quinoline core with strategically positioned amino and hydroxyl groups, enabling versatile integration into bioactive scaffolds. This electron-rich heterocycle exhibits enhanced solubility and stability under standard conditions, facilitating use in medicinal chemistry and materials synthesis workflows.

Application

2-Aminoquinolin-4-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds through standard functional group transformations. Its dual amino and hydroxyl functionalities offer orthogonal reactivity for derivatization, while the core structure exhibits robust bench stability and compatibility with common coupling protocols. The compound functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles, facilitating straightforward purification and integration into complex molecular architectures.

Synthesis

  • Route1
    • In-stock
      Isatoic anhydride|CS-M0780
      118-48-9
    • null|null
      109-77-3
    • ~%
    • In-stock
      2-Aminoquinolin-4-ol|CS-W016163
      42712-64-1

    References

    • Pfizer Inc. Patent: US4175193 A1, 1979 ; Title/Abstract Full Text Show Details Pfizer Inc. Patent: US4247699 A1, 1981 ;
  • Route2

    References

    • Abdou, Wafaa M.; Kamel, Azza A. Synthetic Communications, 2007 , vol. 37, # 22 p. 3945 - 3960
  • Route3
    • null|null
      42712-65-2
    • ~%
    • In-stock
      2-Aminoquinolin-4-ol|CS-W016163
      42712-64-1

    References

    • Tanida Chemical and Pharmaceutical Bulletin, <1959> 887, 891

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   59.14
  • LogP   1.5226
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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