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CS-W001157 4
Total: USD 88.00

(S)-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride

  • CAS No. 426844-51-1

  • Cat. No. CS-0042848
  • Purity≥95%
  • MDL No.MFCD06797014

*For research and further manufacturing use only, not for direct human use.

(S)-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride|CS-0042848

Structure of 426844-51-1

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General Information

  • CAS No. 426844-51-1
  • Cat. No. CS-0042848
  • Purity ≥95%
  • MDL No. MFCD06797014
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉ClF₂N₂O
  • Molecular Weight 186.59
  • Synonym(s) 4,4-Difluoro-l-prolinaMide, HCl
  • SMILES O=C([C@H]1NCC(F)(F)C1)N.[H]Cl

Application

(S)-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride serves as a conformationally constrained, metabolically stable building block for medicinal chemistry. Its difluorinated pyrrolidine core enhances membrane permeability and target binding affinity, while the carboxamide group enables direct incorporation into peptidomimetics and bioactive heterocycles via standard amide coupling protocols. The hydrochloride salt ensures excellent bench stability, solubility, and ease of handling in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.1093
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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