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Structure of 426-59-5
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3-((Trifluoromethyl)sulfonyl)aniline features a trifluoromethylsulfonyl group that imparts strong electron-withdrawing character and enhanced stability. This substitution pattern enables efficient coupling reactions, particularly in cross-coupling and amide formation, where the sulfonyl moiety serves as a robust directing group. The compound exhibits excellent bench stability and solubility in common organic solvents, facilitating its use in synthetic workflows requiring precise functional group control.
3-((Trifluoromethyl)sulfonyl)aniline serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via its reactive triflyl (Tf) group. The electron-withdrawing trifluoromethanesulfonyl moiety enhances the electrophilicity of the adjacent aromatic ring, facilitating nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H302-H312-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P405-P501
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Lot numbers can be found on the outside label of a product: