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CS-W001157 4
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p-Phenylenedipropionicacid

  • CAS No. 4251-21-2

  • Cat. No. CS-0157561
  • Purity≥95%
  • MDL No.MFCD00002779

*For research and further manufacturing use only, not for direct human use.

p-Phenylenedipropionicacid|CS-0157561

Structure of 4251-21-2

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General Information

  • CAS No. 4251-21-2
  • Cat. No. CS-0157561
  • Purity ≥95%
  • MDL No. MFCD00002779
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄O₄
  • Molecular Weight 222.24
  • Synonym(s) p-Phenylenedipropionic acid
  • SMILES O=C(O)CCC1=CC=C(C=C1)CCC(=O)O

Description

p-Phenylenedipropionic acid features a rigid para-substituted aromatic core flanked by two propionic acid side chains, enabling precise spatial control in molecular architectures. This structural rigidity enhances stability in conjugated systems and facilitates integration into functional materials for organic electronics and supramolecular assemblies.

Application

p-Phenylenedipropionic acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of functionalized aromatic scaffolds. Its dual propionic acid groups provide robust polarity and solubility, facilitating purification and downstream derivatization. The molecule exhibits excellent bench stability and functions effectively in coupling reactions, heterocycle synthesis, and peptide analog development where rigid, linear aromatic linkers are required.

Synthesis

  • Route1
    • Dimethyl 3,3'-(1,4-phenylene)diacrylate|CS-0524183
      7549-44-2
    • ~%
    • In-stock
      p-Phenylenedipropionicacid|CS-0157561
      4251-21-2

    References

    • Neudeck, Horst K. Monatshefte fuer Chemie, 1987 , vol. 118, p. 627 - 658
  • Route2

    References

    • Neudeck, Horst K. Monatshefte fuer Chemie, 1987 , vol. 118, p. 627 - 658
  • Route3

    References

    • Tang, Hang; Wijesekera, Tilak P.; Dolphin, David Canadian Journal of Chemistry, 1992 , vol. 70, # 5 p. 1366 - 1374

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   1.721
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   6

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