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1,2-Dioleoyl-sn-glycero-3-phosphocholine

  • CAS No. 4235-95-4

  • Cat. No. CS-0063306
  • Purity≥97%
  • MDL No.MFCD00135191

*For research and further manufacturing use only, not for direct human use.

1,2-Dioleoyl-sn-glycero-3-phosphocholine|CS-0063306

Structure of 4235-95-4

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General Information

  • CAS No. 4235-95-4
  • Cat. No. CS-0063306
  • Purity ≥97%
  • MDL No. MFCD00135191
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₄H₈₄NO₈P
  • Molecular Weight 786.11
  • Synonym(s) DOPC
  • SMILES CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O

Description

Intercalating within lipid bilayers, 18:1 (Δ9-Cis) PC (DOPC) (CAS 4235-95-4) induces membrane fluidity modulation and destabilizes raft microdomains in model systems.

Application

18:1 (Δ9-Cis) PC (DOPC) (CAS 4235-95-4) drives proteoliposome reconstitution by integrating seamlessly into membrane architectures, enabling functional mimicry of native lipid bilayers. This setup streamlines protein embedding studies. Researchers leverage its fluidity and stability to generate uniform lipid vesicles for biophysical assays.

Synthesis

  • Route1

    References

    • Ichihara, Ken'ichi; Iwasaki, Hitomi; Ueda, Kaori; Takizawa, Ryoko; Naito, Hideko; Tomosugi, Mitsuhiro Chemistry and Physics of Lipids, 2005 , vol. 137, # 1-2 p. 94 - 99
  • Route2

    References

    • Tsuboi, Sadao; Takeda, Shinji; Yamasaki, Yasuhisa; Sakai, Takashi; Utaka, Masanori; et al. Chemistry Letters, 1992 , # 8 p. 1417 - 1420
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    • In-stock
      1,2-Dioleoyl-sn-glycero-3-phosphocholine|CS-0063306
      4235-95-4

    References

    • Baer et al. Journal of the American Chemical Society, 1956 , vol. 78, p. 232,235

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 1888
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H331-H336-H351-H361-H372-H412
Precautionary Statements : P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   111.19
  • LogP   11.7242
  • H_Acceptors   8
  • H_Donors   0
  • Rotatable_Bonds   40

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