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CS-W001157 4
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N-Methylhydroxylamine hydrochloride

  • CAS No. 4229-44-1

  • Cat. No. CS-W007348
  • Purity≥98%
  • MDL No.MFCD00012597

*For research and further manufacturing use only, not for direct human use.

N-Methylhydroxylamine hydrochloride|CS-W007348

Structure of 4229-44-1

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General Information

  • CAS No. 4229-44-1
  • Cat. No. CS-W007348
  • Purity ≥98%
  • MDL No. MFCD00012597
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula CH₆ClNO
  • Molecular Weight 83.52
  • Synonym(s) N-Methylhydroxylammonium chloride; N-Methylhydroxylamine hydrochloride
  • SMILES CNO.Cl

Description

Proligos DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. The high coupling efficiency of Proligos DNA phosphoramidites leads to high-yield and high-quality oligonucleotides.Changing the dG protecting group to the dimethylformamidine (dmf) base protecting group enables rapid synthesis of high-purity, high-yieldoligonucleotide, thus increasing the efficiency of high-throughputproduction.Key Features of dG(dmf)dG(dmf) is deprotected faster than the conventional dG(ib): thedeprotection time in concentrated ammonia is reduced to 2 hours at55 C or 1 hour at 65 CThe dG(dmf)-monomer is especially suitable for G-rich sequences:incomplete deprotection is greatly reduced in comparison with theconventional dG(ib)-monomerdG(dmf)-phosphoramidite is as stable in solution as the standard dA(bz)-,dC(bz)- and dT-phosphoramidites dG(dmf)-phosphoramidite can directly substitute for dG(ib)-phosphoramidite No change is required in the reagents commonly used for DNA synthesis(except a low concentration iodine oxidizer i.e., 0.02 M in iodine, should beemployed)DMT-dG(dmf) Phosphoramidite is configured for ABI Synthesizers.

Synthesis

  • Route1
    • (Z)-N-Methyl-1-(2-nitrophenyl)methanimine oxide|CS-1090349
      41106-02-9
    • ~96%
    • In-stock
      N-Methylhydroxylamine hydrochloride|CS-W007348
      4229-44-1
    • null|null
      3717-25-7

    References

    • Synthetic Communications, , vol. 35, # 18 p. 2445 - 2451
  • Route2
    • null|null
      75-52-5
    • ~%
    • In-stock
      N-Methylhydroxylamine hydrochloride|CS-W007348
      4229-44-1

    References

    • Journal of Chemical Research, Miniprint, , # 2 p. 324 - 346
  • Route3
    • null|null
      314768-38-2
    • ~%
    • In-stock
      3,4-Dimethoxybenzaldehyde oxime|CS-0782958
      2169-98-4
    • In-stock
      N-Methylhydroxylamine hydrochloride|CS-W007348
      4229-44-1

    References

    • Synthetic Communications, , vol. 35, # 18 p. 2445 - 2451

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   0.0168
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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