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CS-W001157 4
Total: USD 88.00

5-Nitropyridin-2-amine

  • CAS No. 4214-76-0

  • Cat. No. CS-W016479
  • Purity≥97%
  • MDL No.MFCD00006325

*For research and further manufacturing use only, not for direct human use.

5-Nitropyridin-2-amine|CS-W016479

Structure of 4214-76-0

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General Information

  • CAS No. 4214-76-0
  • Cat. No. CS-W016479
  • Purity ≥97%
  • MDL No. MFCD00006325
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅N₃O₂
  • Molecular Weight None
  • Synonym(s) 5-nitro-2-pyridinamine
  • SMILES O=[N+](C1=CN=C(N)C=C1)[O-]

Description

Reduces endocrine responses

Application

5-Nitropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via standard coupling reactions. Its ortho-diamine motif offers enhanced functional group tolerance and facilitates sequential transformations, including nitro reduction and electrophilic substitution. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for scalable synthesis of pyridine-based API intermediates.

Synthesis

  • Route1
    • null|null
      35235-78-0
    • ~%
    • In-stock
      5-Nitropyridin-2-amine|CS-W016479
      4214-76-0

    References

    • Kandalkar, Sachin R.; Kaduskar, Rahul D.; Ramaiah, Parimi Atchuta; Barawkar, Dinesh A.; Bhuniya, Debnath; Deshpande, Anil M. Tetrahedron Letters, 2013 , vol. 54, # 5 p. 414 - 418
  • Route2

    References

    • Lang, Fengrui; Zewge, Daniel; Houpis, Ioannis N.; Volante Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3251 - 3254
  • Route3
    • null|null
      2530-26-9
    • ~76%
    • In-stock
      5-Nitropyridin-2-amine|CS-W016479
      4214-76-0

    References

    • Bakke, Jan M.; Svensen, Harald; Trevisan, Raffaela Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 4 p. 376 - 378

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   82.05
  • LogP   0.572
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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