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CS-W001157 4
Total: USD 88.00

3,5-Dimethylpyridin-2-amine

  • CAS No. 41995-30-6

  • Cat. No. CS-0005571
  • Purity≥96%
  • MDL No.MFCD11040341

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethylpyridin-2-amine|CS-0005571

Structure of 41995-30-6

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General Information

  • CAS No. 41995-30-6
  • Cat. No. CS-0005571
  • Purity ≥96%
  • MDL No. MFCD11040341
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES NC1=NC=C(C)C=C1C

Description

3,5-Dimethylpyridin-2-amine features a pyridine core with methyl groups at the 3 and 5 positions, enhancing electron density at the nitrogen lone pair. This substitution pattern confers improved solubility and stability in polar solvents while maintaining strong coordination ability. The compound serves as a robust ligand in transition metal catalysis and integrates readily into functionalized heterocycles for pharmaceutical intermediates.

Application

3,5-Dimethylpyridin-2-amine serves as a versatile building block in medicinal chemistry and catalysis, offering enhanced stability and solubility compared to unsubstituted pyridine derivatives. The ortho-dimethyl substitution pattern confers favorable electronic properties and steric protection, enabling reliable coupling reactions and transition metal coordination. Its amine functionality facilitates straightforward derivatization, making it well-suited for the synthesis of kinase inhibitors, ligands, and functionalized heterocycles.

Synthesis

  • Route1

    References

    • GLAXO GROUP LIMITED; ALVARO, Giuseppe; AMANTINI, David Patent: WO2010/72722 A1, 2010 ; Location in patent: Page/Page column 28 ; WO 2010/072722 A1
  • Route2
    • null|null
      591-22-0
    • ~35%
    • In-stock
      3,5-Dimethylpyridin-2-amine|CS-0005571
      41995-30-6

    References

    • Siegl, Walter O. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1613 - 1618
  • Route3
    • null|null
      3718-65-8
    • ~%
    • In-stock
      3,5-Dimethylpyridin-2-amine|CS-0005571
      41995-30-6

    References

    • GLAXO GROUP LIMITED; BIRAULT, Véronique; CAMPBELL, Amanda, Jennifer; HARRISON, Stephen; LE, Joelle; SHUKLA, Lena Patent: WO2013/160419 A1, 2013 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P301+P310-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.28064
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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