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CS-W001157 4
Total: USD 88.00

4-Aminoindazole

  • CAS No. 41748-71-4

  • Cat. No. CS-0007645
  • Purity≥97%
  • MDL No.MFCD03305710

*For research and further manufacturing use only, not for direct human use.

4-Aminoindazole|CS-0007645

Structure of 41748-71-4

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General Information

  • CAS No. 41748-71-4
  • Cat. No. CS-0007645
  • Purity ≥97%
  • MDL No. MFCD03305710
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃
  • Molecular Weight 133.15
  • Synonym(s) 1H-indazol-4-amine
  • SMILES NC1=C2C(NN=C2)=CC=C1

Description

4-Aminoindazole delivers a potent electron-rich heterocyclic scaffold ideal for medicinal chemistry and materials science. This bench-stable, moisture-tolerant compound integrates readily into bioactive molecules, offering enhanced solubility and hydrogen-bonding capacity through its para-amino functionality.

Application

4-Aminoindazole serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its amino group facilitates direct derivatization, while the indazole core provides enhanced metabolic stability and favorable binding interactions. The compound exhibits excellent bench stability and is compatible with common reaction conditions, simplifying purification and scale-up in API development workflows.

Synthesis

  • Route1

    References

    • GENENTECH, INC.; PIRAMED LIMITED Patent: WO2007/127183 A1, 2007 ; Location in patent: Page/Page column 139 ; WO 2007/127183 A1
  • Route2
    • null|null
      1228191-27-2
    • ~93%
    • In-stock
      4-Aminoindazole|CS-0007645
      41748-71-4

    References

    • Stokes, Benjamin J.; Vogel, Carl V.; Urnezis, Linda K.; Pan, Minjie; Driver, Tom G. Organic Letters, 2010 , vol. 12, # 12 p. 2884 - 2887
  • Route3

    References

    • SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; DEOKAR, Rhushikesh, Chandraban; HOLLINGER, Frank, Peter; KAPOOR, Kamal, Kishore Patent: WO2012/101654 A2, 2012 ; WO 2012/101654 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.1451
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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