Methyl 5-bromo-4-fluoro-2-hydroxybenzoate

Name: Methyl 5-bromo-4-fluoro-2-hydroxybenzoate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 4133-72-6
Cat. No. CS-0102033
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 5-bromo-4-fluoro-2-hydroxybenzoate|CS-0102033

Structure of 4133-72-6

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 4133-72-6
Cat. No. CS-0102033
Purity ≥97%
MDL No. None
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆BrFO₃
Molecular Weight 249.03
Synonym(s) 5-BroMo-4-fluoro-2-hydroxy-benzoic acid Methyl ester
SMILES O=C(OC)C1=CC(Br)=C(F)C=C1O

Description

Methyl 5-bromo-4-fluoro-2-hydroxybenzoate features a trifunctional aromatic core with orthogonal reactivity. The ortho-hydroxyl group enables chelation or derivatization, while the bromo and fluoro substituents serve as handles for palladium-catalyzed cross-coupling and nucleophilic substitution. This electron-deficient scaffold integrates readily into complex molecular architectures under standard conditions.

Application

Methyl 5-bromo-4-fluoro-2-hydroxybenzoate serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling selective functionalization at the hydroxy and carboxylate positions. The ortho-hydroxy group facilitates intramolecular cyclization or metal-catalyzed coupling reactions, while the bromo and fluoro substituents support sequential cross-coupling transformations under mild conditions. Its bench-stable nature and compatibility with standard purification protocols make it well-suited for multi-step synthesis workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 46.53
LogP 2.0804
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

4133-72-6 sigma4133-72-6 manufacturer4133-72-6 price4133-72-6 structure4133-72-6 SDSbuy 4133-72-64133-72-6 supplier4133-72-6 uses4133-72-6 molecular weightprice of 4133-72-64133-72-6 chemical name formula of 4133-72-6

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Methyl 5-bromo-4-fluoro-2-hydroxybenzoate

CAS No. 4133-72-6

Recommended Products