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CS-W001157 4
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5-Bromo-3-methyl-1-phenyl-1H-pyrazole

  • CAS No. 41327-15-5

  • Cat. No. CS-0059930
  • Purity≥98%
  • MDL No.MFCD00462191

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-methyl-1-phenyl-1H-pyrazole|CS-0059930

Structure of 41327-15-5

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General Information

  • CAS No. 41327-15-5
  • Cat. No. CS-0059930
  • Purity ≥98%
  • MDL No. MFCD00462191
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉BrN₂
  • Molecular Weight 237.10
  • Synonym(s) 5-Bromo-3-methyl-1-phenylpyrazole
  • SMILES CC(C=C1Br)=NN1C2=CC=CC=C2

Description

5-Bromo-3-methyl-1-phenyl-1H-pyrazole features a brominated pyrazole core with a methyl group at the 3-position and a phenyl substituent at N1, delivering enhanced electronic modulation and steric profile. This bench-stable heterocycle integrates readily into cross-coupling workflows and serves as a key scaffold in medicinal chemistry for targeted kinase inhibition and bioactive molecule construction.

Application

5-Bromo-3-methyl-1-phenyl-1H-pyrazole serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. The bromo group enables palladium-catalyzed cross-coupling reactions, while the methyl and phenyl substituents provide defined steric and electronic profiles. Its stability under standard reaction conditions facilitates purification and integration into complex molecular architectures.

Synthesis

  • Route1
    • Edaravone solution|CS-1692864
      89-25-8
    • ~%
    • In-stock
      5-Bromo-3-methyl-1-phenyl-1H-pyrazole|CS-0059930
      41327-15-5

    References

    • Michaelis; Behn Chemische Berichte, 1900 , vol. 33, p. 2599 Full Text Show Details Stoermer Chemische Berichte, 1903 , vol. 36, p. 3988 Chemische Berichte, 1907 , vol. 40, p. 484
  • Route2

    References

    • Michaelis; Behn Chemische Berichte, 1900 , vol. 33, p. 2599 Full Text Show Details Stoermer Chemische Berichte, 1903 , vol. 36, p. 3988 Chemische Berichte, 1907 , vol. 40, p. 484
  • Route3
    • null|null
      74-96-4
    • Terilitin impurity 17|CS-0013006
      1131-17-5
    • ~%
    • In-stock
      5-Bromo-3-methyl-1-phenyl-1H-pyrazole|CS-0059930
      41327-15-5

    References

    • Michaelis; Behn Chemische Berichte, 1900 , vol. 33, p. 2599

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.94322
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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