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CS-W001157 4
Total: USD 88.00

2,4-Dimethylpyrimidin-5-ol

  • CAS No. 412003-95-3

  • Cat. No. CS-W005733
  • Purity≥97%
  • MDL No.MFCD18072447
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-Dimethylpyrimidin-5-ol|CS-W005733

Structure of 412003-95-3

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Description

2,4-Dimethylpyrimidin-5-ol features a pyrimidine core bearing methyl groups at positions 2 and 4, enhancing steric protection of the C5 hydroxyl. This bench-stable derivative exhibits improved solubility in organic solvents compared to unsubstituted analogs, enabling straightforward incorporation into synthetic sequences. The hydroxyl group serves as a versatile handle for derivatization, facilitating coupling reactions under mild conditions. Its electron-rich character supports efficient metal-catalyzed transformations, making it a valuable scaffold in medicinal chemistry and materials synthesis.

Application

2,4-Dimethylpyrimidin-5-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate downstream functionalization. The molecule functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles, offering predictable reactivity and straightforward purification.

General Information

  • CAS No. 412003-95-3
  • Cat. No. CS-W005733
  • Purity ≥97%
  • MDL No. MFCD18072447
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) 5-Pyrimidinol, 2,4-dimethyl- (9CI)
  • SMILES OC1=CN=C(C)N=C1C

Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.79904
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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