Piperidine-1-sulfonamide

Name: Piperidine-1-sulfonamide
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 4108-90-1
Cat. No. CS-0503493
Molecule weight164.23
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 4108-90-1

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General Information

CAS No. 4108-90-1
Cat. No. CS-0503493
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₂N₂O₂S
Molecular Weight 164.23
Synonym(s) 1-Piperidinesulfonamide(6CI,7CI,8CI,9CI)
SMILES NS(=O)(=O)N1CCCCC1

Description

Piperidine-1-sulfonamide features a sulfonamide group attached to the nitrogen atom of a piperidine ring, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into medicinal chemistry libraries, serving as a key heterocyclic motif for optimizing pharmacokinetic profiles in bioactive compounds.

Application

Piperidine-1-sulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide coupling and electrophilic substitution reactions. Its sulfonamide group exhibits good bench stability and facilitates hydrogen bonding interactions in target binding sites. The molecule functions effectively in multi-step syntheses due to its functional group tolerance and ease of purification, making it a practical choice for scaffold diversification in API development workflows.

Synthesis

Route1
- 110-89-4
- ~63%
- In-stock
  
  4108-90-1
References
- McDermott, Sean D.; Spillane, William J. Synthesis, 1983 , # 3 p. 192 - 195
Route2
- 110-89-4
- 108555-00-6
- ~%
- In-stock
  
  4108-90-1
- 100-02-7
References
- McCaw, Cheryl J. A.; Spillane, William J. Journal of Physical Organic Chemistry, 2006 , vol. 19, # 8-9 p. 512 - 517

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 63.4
LogP -0.3242
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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Piperidine-1-sulfonamide

CAS No. 4108-90-1

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