5'-Amino-5'-deoxyguanosine

Name: 5'-Amino-5'-deoxyguanosine
Brand: ChemScene
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CAS No. 4099-84-7
Cat. No. CS-0097024
Purity≥95%
MDL No.MFCD22124271

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 4099-84-7
Cat. No. CS-0097024
Purity ≥95%
MDL No. MFCD22124271
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₄N₆O₄
Molecular Weight 282.26
Synonym(s) 2-amino-9-((2R,3R,4S,5R)-5-(aminomethyl)-3,4-dihydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one
SMILES O[C@H]1[C@@H](O)[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O[C@@H]1CN

Description

5'-Amino-5'-deoxyguanosine offers a reactive amine handle at the 5' position, enabling site-specific conjugation in nucleic acid synthesis. This modified guanosine derivative features a bench-stable, moisture-tolerant scaffold ideal for bioconjugation workflows. The absence of a 5'-hydroxyl group simplifies protection strategies while maintaining compatibility with standard phosphoramidite chemistry.

Application

5'-Amino-5'-deoxyguanosine serves as a valuable building block for nucleoside analog synthesis, enabling site-specific modifications at the 5'-position. Its amino group facilitates conjugation and derivatization under mild conditions, while the intact purine core supports standard coupling reactions. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for medicinal chemistry campaigns targeting oligonucleotide therapeutics and modified nucleoside scaffolds.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 165.3
LogP -2.7203
H_Acceptors 9
H_Donors 5
Rotatable_Bonds 2

Key Words

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5'-Amino-5'-deoxyguanosine

CAS No. 4099-84-7

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