Oxazolo[4,5-b]pyridin-2-amine

Name: Oxazolo[4,5-b]pyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 40926-66-7
Cat. No. CS-0208312
Purity≥97%
MDL No.MFCD11110210

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Oxazolo[4,5-b]pyridin-2-amine|CS-0208312

Structure of 40926-66-7

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General Information

CAS No. 40926-66-7
Cat. No. CS-0208312
Purity ≥97%
MDL No. MFCD11110210
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅N₃O
Molecular Weight None
Synonym(s) 2-Aminooxazolopyridin
SMILES NC1=NC2=NC=CC=C2O1

Description

Oxazolo[4,5-b]pyridin-2-amine delivers a rigid, electron-rich heterocyclic scaffold ideal for medicinal chemistry. This fused bicyclic system integrates a primary amine at the 2-position, enabling direct conjugation or derivatization. The structure exhibits enhanced metabolic stability and favorable binding geometry in kinase-targeted drug discovery.

Application

Oxazolo[4,5-b]pyridin-2-amine serves as a privileged heterocyclic scaffold in medicinal chemistry, enabling rapid access to bioactive molecules through its inherent nitrogen-rich architecture. The compound functions as a versatile building block in transition-metal-catalyzed couplings and direct functionalization reactions, leveraging its amine handle for conjugation and derivatization. Its robust bench stability and compatibility with diverse reaction conditions facilitate efficient synthesis of kinase inhibitors and other targeted therapeutics.

Synthesis

Route1
- In-stock
  
  16867-03-1
- 506-68-3
- ~77%
- In-stock
  
  40926-66-7
References
- Brotherton-Pleiss, Christine E.; Walker, Keith A. M. Patent: US2012/149718 A1, 2012 ; Location in patent: Page/Page column 34 ; US 20120149718 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 64.94
LogP 0.805
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Oxazole compounds

Key Words

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Oxazolo[4,5-b]pyridin-2-amine

CAS No. 40926-66-7

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