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CS-W001157 4
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α-Lipoic acid-NHS

  • CAS No. 40846-94-4

  • Cat. No. CS-0115098
  • Purity≥98%
  • MDL No.MFCD09028032

*For research and further manufacturing use only, not for direct human use.

α-Lipoic acid-NHS|CS-0115098

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General Information

  • CAS No. 40846-94-4
  • Cat. No. CS-0115098
  • Purity ≥98%
  • MDL No. MFCD09028032
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO₄S₂
  • Molecular Weight 303.40
  • Synonym(s) DL-α-Lipoic acid-NHS
  • SMILES O=C(ON1C(CCC1=O)=O)CCCCC2SSCC2

Description

α-Lipoic acid-NHS ester enables efficient conjugation of thiol-containing biomolecules under physiological conditions. This reactive derivative features a stable NHS group that couples selectively with primary amines, facilitating site-specific labeling and bioconjugation in drug delivery and probe development workflows.

Synthesis

  • Route1
    • In-stock
      HOSU Amino acid impurity|CS-1733141
      6066-82-6
    • Thioctic acid solution|CS-1692905
      1077-28-7
    • ~10%
    • In-stock
      α-Lipoic acid-NHS|CS-0115098
      40846-94-4

    References

    • Shi, Lei; Jing, Chao; Ma, Wei; Li, Da-Wei; Halls, Jonathan E.; Marken, Frank; Long, Yi-Tao Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6011 - 6014 Angew. Chem., 2013 , vol. 125, # 23 p. 6127 - 6130,4
  • Route2

    References

    • Kates, Steven A.; Casale, Ralph A.; Baguisi, Alexander; Beeuwkes III, Reinier Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 505 - 512

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H315-H319-H372-H410
Precautionary Statements : P260-P264-P270-P273-P280-P302+P352-P362+P364-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.68
  • LogP   2.3077
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   6

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