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CS-W001157 4
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7-Bromo-5-methoxy-1H-indole

  • CAS No. 408355-12-4

  • Cat. No. CS-0529047
  • Purity≥96%
  • MDL No.MFCD04037873

*For research and further manufacturing use only, not for direct human use.

7-Bromo-5-methoxy-1H-indole|CS-0529047

Structure of 408355-12-4

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General Information

  • CAS No. 408355-12-4
  • Cat. No. CS-0529047
  • Purity ≥96%
  • MDL No. MFCD04037873
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈BrNO
  • Molecular Weight 226.07
  • Synonym(s) 7-bromo-5-methoxyindole
  • SMILES COC1=CC2=C(NC=C2)C(Br)=C1

Description

7-Bromo-5-methoxy-1H-indole is a halogenated indole derivative featuring a bromine substituent at the 7-position and a methoxy group at the 5-position. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key building block for bioactive heterocycles in medicinal chemistry and materials science.

Application

7-Bromo-5-methoxy-1H-indole serves as a versatile building block for medicinal chemistry and materials science, enabling direct functionalization at the C3 position via palladium-catalyzed cross-coupling. The bromo group provides high reactivity in Suzuki, Stille, and Negishi reactions, while the methoxy substituent enhances solubility and modulates electronic properties. Bench-stable and readily purified by flash chromatography, it functions reliably in multistep syntheses of heterocyclic scaffolds and bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.02
  • LogP   2.939
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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