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5-Carboxy-2-acetylthiophene

  • CAS No. 4066-41-5

  • Cat. No. CS-B1379
  • Purity≥98%
  • MDL No.MFCD00055512

*For research and further manufacturing use only, not for direct human use.

5-Carboxy-2-acetylthiophene|CS-B1379

Structure of 4066-41-5

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General Information

  • CAS No. 4066-41-5
  • Cat. No. CS-B1379
  • Purity ≥98%
  • MDL No. MFCD00055512
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆O₃S
  • Molecular Weight 170.19
  • Synonym(s) 5-Acetyl-2-thiophenecarboxylic acid; 5-Acetylthiophene-2-carboxylic acid
  • SMILES O=C(C1=CC=C(C(C)=O)S1)O

Description

6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.

Application

5-Carboxy-2-acetylthiophene serves as a versatile building block in heterocyclic synthesis, enabling efficient access to functionalized thiophene scaffolds. Its dual functionality—carboxylic acid and acetyl group—facilitates sequential transformations, including amidation, esterification, and condensation reactions, with good bench stability and straightforward purification. This compound functions as a key intermediate in the construction of bioactive heterocycles and pharmaceutical candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   1.6489
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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