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Structure of 406476-31-1
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This piperidine-based scaffold features a trifluoromethyl-substituted pyridine moiety, delivering enhanced electron-withdrawing character and metabolic stability. The carboxylic acid group enables direct conjugation or derivatization, while the rigidified core supports precise spatial orientation in target engagement. Ideal for medicinal chemistry campaigns requiring lipophilic, bioactive motifs with improved pharmacokinetic profiles.
1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid serves as a versatile building block for medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its trifluoromethyl-pyridine moiety enhances metabolic stability and membrane permeability, while the piperidine carboxylic acid functionality facilitates amide coupling and salt formation. The compound exhibits bench stability, tolerates standard reaction conditions, and supports efficient purification—ideal for iterative lead optimization in drug discovery programs.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: