Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid

  • CAS No. 406476-31-1

  • Cat. No. CS-0072348
  • Molecule weight274.24
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid|CS-0072348

Structure of 406476-31-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 406476-31-1
  • Cat. No. CS-0072348
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₃F₃N₂O₂
  • Molecular Weight 274.24
  • Synonym(s) 5'-TRIFLUOROMETHYL-3,4,5,6-TETRAHYDRO-2H-[1,2']BIPYRIDINYL-4-CARBOXYLIC ACID
  • SMILES O=C(O)C1CCN(CC1)C2=NC=C(C=C2)C(F)(F)F

Description

This piperidine-based scaffold features a trifluoromethyl-substituted pyridine moiety, delivering enhanced electron-withdrawing character and metabolic stability. The carboxylic acid group enables direct conjugation or derivatization, while the rigidified core supports precise spatial orientation in target engagement. Ideal for medicinal chemistry campaigns requiring lipophilic, bioactive motifs with improved pharmacokinetic profiles.

Application

1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid serves as a versatile building block for medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its trifluoromethyl-pyridine moiety enhances metabolic stability and membrane permeability, while the piperidine carboxylic acid functionality facilitates amide coupling and salt formation. The compound exhibits bench stability, tolerates standard reaction conditions, and supports efficient purification—ideal for iterative lead optimization in drug discovery programs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   53.43
  • LogP   2.4014
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 406476-31-1 sigma406476-31-1 manufacturer406476-31-1 price406476-31-1 structure406476-31-1 SDSbuy 406476-31-1406476-31-1 supplier406476-31-1 uses406476-31-1 molecular weightprice of 406476-31-1406476-31-1 chemical name formula of 406476-31-1
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label