5-Chloro-1-methyl-1H-pyrazol-4-amine

Name: 5-Chloro-1-methyl-1H-pyrazol-4-amine
Brand: ChemScene
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CAS No. 406189-04-6
Cat. No. CS-0058327
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Chloro-1-methyl-1H-pyrazol-4-amine|CS-0058327

Structure of 406189-04-6

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General Information

CAS No. 406189-04-6
Cat. No. CS-0058327
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₆ClN₃
Molecular Weight 131.56
Synonym(s) None
SMILES NC1=C(Cl)N(C)N=C1

Description

5-Chloro-1-methyl-1H-pyrazol-4-amine features a chlorinated pyrazole core with a methylated nitrogen at the 1-position, delivering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key heterocyclic building block in medicinal chemistry for targeted kinase inhibitors and antiparasitic agents.

Application

5-Chloro-1-methyl-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyrazole scaffolds. Its chloro group facilitates palladium-catalyzed cross-coupling reactions, while the N-methylated pyrazole nitrogen enhances metabolic stability and modulates solubility. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 43.84
LogP 0.6557
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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5-Chloro-1-methyl-1H-pyrazol-4-amine

CAS No. 406189-04-6

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