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CS-W001157 4
Total: USD 88.00

2,5-Dichloropyridin-4-amine

  • CAS No. 405230-82-2

  • Cat. No. CS-W018938
  • Purity≥98%
  • MDL No.MFCD11044256

*For research and further manufacturing use only, not for direct human use.

2,5-Dichloropyridin-4-amine|CS-W018938

Structure of 405230-82-2

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General Information

  • CAS No. 405230-82-2
  • Cat. No. CS-W018938
  • Purity ≥98%
  • MDL No. MFCD11044256
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄Cl₂N₂
  • Molecular Weight 163.01
  • Synonym(s) 4-Pyridinamine,2,5-dichloro-(9CI)
  • SMILES NC1=CC(Cl)=NC=C1Cl

Description

2,5-Dichloropyridin-4-amine features a pyridine core bearing two chlorine substituents at the 2 and 5 positions and an amino group at the 4-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct coupling reactions through its nucleophilic amine and halogenation sites. The molecule exhibits enhanced stability under standard conditions and facilitates efficient diversification in target-oriented synthesis.

Application

2,5-Dichloropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 4-position via nucleophilic substitution. Its dichloro substitution pattern provides orthogonal reactivity for sequential coupling processes, while the amine group facilitates amidation, sulfonamide formation, and transition-metal-catalyzed cross-couplings. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it ideal for scalable synthesis of heterocyclic scaffolds found in agrochemicals and pharmaceuticals.

Synthesis

  • Route1
    • null|null
      405230-81-1
    • ~85%
    • In-stock
      2,5-Dichloropyridin-4-amine|CS-W018938
      405230-82-2

    References

    • Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
  • Route2

    References

    • Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
  • Route3
    • null|null
      53976-62-8
    • ~%
    • In-stock
      2,5-Dichloropyridin-4-amine|CS-W018938
      405230-82-2

    References

    • Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅱ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.9706
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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