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Structure of 405-04-9
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3-Fluoro-4-hydroxybenzonitrile features a strategically positioned hydroxyl group and nitrile moiety on a fluorinated aromatic ring, enabling direct coupling in Suzuki-Miyaura and Ullmann reactions. This bench-stable scaffold integrates readily into bioactive heterocycles and pharmaceutical intermediates, offering enhanced solubility and metabolic stability in drug discovery workflows.
3-Fluoro-4-hydroxybenzonitrile serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling efficient access to substituted benzene scaffolds. Its orthogonal functional groups—fluorine, hydroxyl, and nitrile—permit selective transformations under standard conditions, including nucleophilic substitution, coupling reactions, and derivatization via the hydroxyl group. Bench-stable and readily purified by crystallization, it functions effectively in multi-step syntheses requiring precise regiocontrol and compatibility with diverse reaction environments.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H312-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P363-P405-P501
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Lot numbers can be found on the outside label of a product: