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CS-W001157 4
Total: USD 88.00

3,4-Difluorostyrene,98% (stabilized with TBC)

  • CAS No. 405-03-8

  • Cat. No. CS-0113814
  • Purity98% (stabilized with TBC)
  • MDL No.MFCD09038471

*For research and further manufacturing use only, not for direct human use.

3,4-Difluorostyrene,98% (stabilized with TBC)|CS-0113814

Structure of 405-03-8

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General Information

  • CAS No. 405-03-8
  • Cat. No. CS-0113814
  • Purity 98% (stabilized with TBC)
  • MDL No. MFCD09038471
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₂
  • Molecular Weight 140.13
  • Synonym(s) 4-Ethenyl-1,2-difluorobenzene
  • SMILES FC1=CC(C=C)=CC=C1F

Description

3,4-Difluorostyrene, 98% (stabilized with TBC) features a dual fluorine substitution at the ortho positions of the phenyl ring, enhancing electron deficiency and metabolic stability. The para-vinyl group enables efficient coupling in cross-coupling reactions. Stabilized with TBC to inhibit polymerization during storage and handling. Bench-stable under standard conditions.

Application

3,4-Difluorostyrene (98%, stabilized with TBC) serves as a valuable building block for fluorinated aromatic systems, enabling efficient incorporation of ortho-difluoro substitution into pharmaceutical and agrochemical scaffolds. The stabilizer (TBC) enhances shelf stability and handling safety, while the vinyl functionality facilitates robust cross-coupling reactions, including Suzuki-Miyaura and Heck processes. Its bench-stable nature and compatibility with standard reaction conditions make it a practical choice for synthetic chemists developing fluorinated heterocycles and bioactive molecules.

Synthesis

  • Route1
    • 3,4-Difluorobenzaldehyde  Ticagrelor Impurity|CS-0167233
      34036-07-2
    • null|null
      1779-49-3
    • ~%
    • In-stock
      3,4-Difluorostyrene,98% (stabilized with TBC)|CS-0113814
      405-03-8

    References

    • Sung, Jin Cho; Jensen, Niels H.; Kurome, Toru; Kadari, Sudhakar; Manzano, Michael L.; Malberg, Jessica E.; Caldarone, Barbara; Roth, Bryan L.; Kozikowski, Alan P. Journal of Medicinal Chemistry, 2009 , vol. 52, # 7 p. 1885 - 1902

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.6078
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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