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CS-W001157 4
Total: USD 88.00

5-Methyl-1,2,4-oxadiazol-3-amine

  • CAS No. 40483-47-4

  • Cat. No. CS-W022407
  • Purity≥98%
  • MDL No.MFCD08272077

*For research and further manufacturing use only, not for direct human use.

5-Methyl-1,2,4-oxadiazol-3-amine|CS-W022407

Structure of 40483-47-4

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General Information

  • CAS No. 40483-47-4
  • Cat. No. CS-W022407
  • Purity ≥98%
  • MDL No. MFCD08272077
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₅N₃O
  • Molecular Weight 99.09
  • Synonym(s) None
  • SMILES NC1=NOC(C)=N1

Description

5-Methyl-1,2,4-oxadiazol-3-amine features a nitrogen-rich heterocyclic core with a methyl-substituted oxadiazole ring, delivering enhanced stability and solubility in polar solvents. This scaffold integrates readily into bioactive molecules, serving as a key building block for pharmaceutical intermediates and agrochemicals.

Application

5-Methyl-1,2,4-oxadiazol-3-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through established coupling and functionalization protocols. Its stable oxadiazole core exhibits favorable bench handling and functional group tolerance, facilitating downstream derivatization in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      10349-15-2
    • ~81%
    • In-stock
      5-Methyl-1,2,4-oxadiazol-3-amine|CS-W022407
      40483-47-4

    References

    • Buscemi; Vivona; Caronna Synthesis, 1995 , # 8 p. 917 - 919
  • Route2
    • null|null
      5228-92-2
    • ~%
    • In-stock
      5-Methyl-1,2,4-oxadiazol-3-amine|CS-W022407
      40483-47-4

    References

    • Eloy,F.; Lenaers,R. Helvetica Chimica Acta, 1966 , vol. 49, p. 1430 - 1432
  • Route3
    • In-stock
      Cyanamide|CS-0008351
      420-04-2
    • null|null
      108-24-7
    • ~37%
    • In-stock
      5-Methyl-1,2,4-oxadiazol-3-amine|CS-W022407
      40483-47-4

    References

    • Buscemi, Silvestre; Pace, Andrea; Frenna, Vincenzo; Vivona, Nicolo Heterocycles, 2002 , vol. 57, # 5 p. 811 - 823

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.94
  • LogP   -0.03978
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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