Lot numbers can be found on the outside label of a product:
1-Benzhydrylazetidin-3-amine
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CAS No. 40432-52-8
- Cat. No. CS-D0678
- Purity≥98%
- MDL No.MFCD03093386
*For research and further manufacturing use only, not for direct human use.
Structure of 40432-52-8
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General Information
- CAS No. 40432-52-8
- Cat. No. CS-D0678
- Purity ≥98%
- MDL No. MFCD03093386
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₆H₁₈N₂
- Molecular Weight 238.33
- Synonym(s) 3-Amino-1-diphenylmethylazetidine
- SMILES NC1CN(C1)C(C2=CC=CC=C2)C3=CC=CC=C3
Description
1-Benzhydrylazetidin-3-amine is a sterically hindered, bench-stable azetidine derivative featuring a benzhydryl group at the nitrogen. This configuration enhances metabolic stability and modulates solubility, enabling efficient incorporation into bioactive molecules. The scaffold serves as a key building block in medicinal chemistry, particularly for targeting kinase pathways and optimizing pharmacokinetic profiles in drug discovery campaigns.
Application
1-Benzhydrylazetidin-3-amine serves as a versatile chiral building block in medicinal chemistry, enabling the construction of azetidine-containing scaffolds with enhanced metabolic stability. Its benzhydryl group provides steric and electronic modulation, while the primary amine facilitates straightforward functionalization via acylation, alkylation, or conjugate addition. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for use in iterative synthesis campaigns targeting bioactive heterocycles.
Synthesis
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Route1
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143699-92-7 - ~65%
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In-stock
40432-52-8
References
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DAIICHI PHARMACEUTICAL CO., LTD. Patent: EP1591443 A1, 2005 ; Location in patent: Page/Page column 67-68 ;
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Route2
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38353-74-1 - ~95%
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In-stock
40432-52-8
References
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Nisato; Frigerio Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 961 - 963
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Route3
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In-stock
33301-41-6 - ~88%
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In-stock
40432-52-8
References
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Luzzio, Michael Joseph; Yang, Bingwei Vera; Marx, Matthew Arnold Patent: US2002/42409 A1, 2002 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.26
- LogP 2.4189
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 3
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Key Words
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