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CS-W001157 4
Total: USD 88.00

2-Bromo-4'-fluoroacetophenone

  • CAS No. 403-29-2

  • Cat. No. CS-W009314
  • Purity≥98%
  • MDL No.MFCD00040830

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4'-fluoroacetophenone|CS-W009314

Structure of 403-29-2

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General Information

  • CAS No. 403-29-2
  • Cat. No. CS-W009314
  • Purity ≥98%
  • MDL No. MFCD00040830
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO
  • Molecular Weight 217.04
  • Synonym(s) p-Fluorophenacyl bromide
  • SMILES BrCC(C1=CC=C(F)C=C1)=O

Description

2-Bromo-4'-fluoroacetophenone features a bromine atom at the ortho position and a fluorine substituent at the para position relative to the acetyl group, creating a highly functionalized aryl electrophile. This electron-deficient scaffold enables efficient coupling reactions in cross-coupling and nucleophilic substitution processes, offering predictable regiochemistry for synthetic applications in pharmaceutical intermediates and agrochemical development.

Synthesis

  • Route1

    References

    • Laufer, Stefan A.; Hauser, Dominik R. J.; Liedtke, Andy J. Synthesis, 2008 , # 2 p. 253 - 266
  • Route2
    • 1-(Bromoethynyl)-4-fluorobenzene|CS-1194533
      95895-33-3
    • ~93%
    • In-stock
      2-Bromo-4'-fluoroacetophenone|CS-W009314
      403-29-2

    References

    • Xie, Longyong; Wu, Yundong; Yi, Weiguo; Zhu, Lei; Xiang, Jiannan; He, Weimin Journal of Organic Chemistry, 2013 , vol. 78, # 18 p. 9190 - 9195
  • Route3
    • null|null
      405-99-2
    • ~87%
    • In-stock
      2-Bromo-4'-fluoroacetophenone|CS-W009314
      403-29-2

    References

    • Jiang, Qing; Sheng, Wenbing; Guo, Cancheng Green Chemistry, 2013 , vol. 15, # 8 p. 2175 - 2179

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4033
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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