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CS-W001157 4
Total: USD 88.00

2-Bromo-5-(trifluoromethyl)phenol

  • CAS No. 402-05-1

  • Cat. No. CS-W019293
  • Purity≥96%
  • MDL No.MFCD09261190
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-(trifluoromethyl)phenol|CS-W019293

Structure of 402-05-1

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Description

2-Bromo-5-(trifluoromethyl)phenol features a trifluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability, while the bromo substituent enables facile cross-coupling transformations. This phenolic scaffold integrates readily into pharmaceutical intermediates and functional materials under standard conditions.

Application

2-Bromo-5-(trifluoromethyl)phenol serves as a versatile building block in the synthesis of functionalized aromatic scaffolds, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the phenolic hydroxyl offers sites for etherification or esterification. Its trifluoromethyl substituent enhances metabolic stability and lipophilicity, making it valuable in medicinal chemistry and agrochemical development. Bench-stable and readily purified by recrystallization, it integrates seamlessly into standard synthetic workflows.

General Information

  • CAS No. 402-05-1
  • Cat. No. CS-W019293
  • Purity ≥96%
  • MDL No. MFCD09261190
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrF₃O
  • Molecular Weight 241.01
  • Synonym(s) phenol, 2-bromo-5-(trifluoromethyl)-
  • SMILES BrC1=C(C=C(C=C1)C(F)(F)F)O

Computational Chemistry Data

  • TPSA   20.23
  • LogP   3.1735
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group :
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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