Lot numbers can be found on the outside label of a product:
4-Chloro-2-methylbenzaldehyde
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CAS No. 40137-29-9
- Cat. No. CS-W002935
- Purity≥95%
- MDL No.MFCD02261735
*For research and further manufacturing use only, not for direct human use.
Structure of 40137-29-9
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General Information
- CAS No. 40137-29-9
- Cat. No. CS-W002935
- Purity ≥95%
- MDL No. MFCD02261735
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₇ClO
- Molecular Weight 154.59
- Synonym(s) Benzaldehyde, 4-chloro-2-methyl-; 4-Chloro-2-methylbenzaldehyde
- SMILES O=Cc1ccc(cc1C)Cl
Description
4-Chloro-2-methylbenzaldehyde features a chlorine atom at the para position and a methyl group at the ortho position relative to the aldehyde, creating a sterically hindered, electron-deficient aromatic ring. This configuration enhances reactivity in nucleophilic addition and coupling reactions, particularly in pharmaceutical synthesis and agrochemical intermediates. The compound exhibits bench-stable handling characteristics under standard conditions.
Application
4-Chloro-2-methylbenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted aromatic scaffolds. Its ortho-methyl and para-chloro substituents provide distinct electronic and steric modulation, enhancing reactivity in nucleophilic additions, condensation reactions, and transition-metal-catalyzed couplings. The aldehyde functionality offers high synthetic versatility for downstream transformations including imine formation, reductive amination, and Ullmann-type coupling processes. Bench-stable and readily purified by distillation or recrystallization, it supports scalable applications in both research and process development workflows.
Synthesis
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Route1
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201230-82-2 -
108-41-8
- ~%
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In-stock
40137-29-9
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In-stock
50817-80-6
References
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MITSUBISHI GAS CHEMICAL COMPANY, INC. Patent: EP1544189 A1, 2005 ; Location in patent: Page/Page column 6 ;
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Route2
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In-stock
104-88-1 -
142-25-6
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74-88-4
- ~%
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In-stock
40137-29-9
References
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The Boots Company PLC Patent: US5547972 A1, 1996 ;
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Route3
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615-60-1 - ~89%
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In-stock
40137-29-9
References
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Li, Wen-Shan; Liu, Lilian Kao Synthesis, 1989 , # 4 p. 293 - 295
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 17.07
- LogP 2.46092
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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