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CS-W001157 4
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6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

  • CAS No. 40107-93-5

  • Cat. No. CS-W006290
  • Molecule weight134.14
  • Purity≥98%
  • MDL No.MFCD12923779

*For research and further manufacturing use only, not for direct human use.

6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one|CS-W006290

Structure of 40107-93-5

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General Information

  • CAS No. 40107-93-5
  • Cat. No. CS-W006290
  • Purity ≥98%
  • MDL No. MFCD12923779
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₂O
  • Molecular Weight 134.14
  • Synonym(s) 6,7-dihydropyrrolo[3,4-b]pyridin-5-one
  • SMILES O=C1NCC2=C1C=CC=N2

Description

6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one is a heterocyclic scaffold featuring a fused pyrrole-pyridinone core with enhanced stability and solubility in polar solvents. This electron-rich system serves as a key building block for medicinal chemistry applications, particularly in kinase inhibitor design and CNS-targeted therapeutics.

Application

6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one serves as a valuable heterocyclic building block in medicinal chemistry, enabling efficient access to pyrrolopyridine scaffolds found in bioactive compounds. Its planar structure and defined polarity facilitate functionalization at multiple sites, while the lactam functionality enhances solubility and provides a handle for derivatization. The compound exhibits good bench stability and is compatible with standard coupling and reduction protocols, making it well-suited for modular synthesis workflows.

Synthesis

  • Route1

    References

    • Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A. European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 58 - 66,9
  • Route2

    References

    • Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A. European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 58 - 66,9

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   0.325
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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