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CS-W001157 4
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(Methoxymethyl)triphenylphosphonium chloride

  • CAS No. 4009-98-7

  • Cat. No. CS-W007624
  • Purity≥98%
  • MDL No.MFCD00011800

*For research and further manufacturing use only, not for direct human use.

(Methoxymethyl)triphenylphosphonium chloride|CS-W007624

Structure of 4009-98-7

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General Information

  • CAS No. 4009-98-7
  • Cat. No. CS-W007624
  • Purity ≥98%
  • MDL No. MFCD00011800
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₀ClOP
  • Molecular Weight 342.80
  • Synonym(s) phosphorane, chloromethoxytriphenyl-; (Methoxymethyl)triphenylphosphonium chloride
  • SMILES COC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Cl-]

Description

(Methoxymethyl)triphenylphosphonium chloride is a Wittig reagent that reacts with aldehydes and ketones to give substituted alkenes. This Wittig reaction finds application as the key step in the synthesis of:Antimalarial drug, (+)-artemisinin.Substituted quinolines.Akuammiline alkaloid picrinine.7H-pyrrolo[2,3-d]pyrimidine derivatives for signal transducers and activators of transcription 6 (STAT6) inhibitors.

Application

(Methoxymethyl)triphenylphosphonium chloride serves as a stable, bench-ready Wittig reagent precursor, enabling efficient synthesis of terminal alkenes from aldehydes. Its methoxymethyl group enhances solubility and simplifies purification, while the triphenylphosphonium moiety ensures high-yielding olefination under standard conditions. Functions reliably in diverse synthetic workflows requiring stereoselective alkene formation.

Synthesis

  • Route1
    • null|null
      107-30-2
    • null|null
      603-35-0
    • ~99%
    • In-stock
      (Methoxymethyl)triphenylphosphonium chloride|CS-W007624
      4009-98-7

    References

    • Xing, Ping; Huang, Zuo-Gang; Jin, Yun; Jiang, Biao Synthesis (Germany), 2013 , vol. 45, # 5 art. no. SS-2012-F0885-OP, p. 596 - 600

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H411
Precautionary Statements : P264-P270-P273-P280-P302+P352-P330-P362+P364-P391-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   0.5884
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   5

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