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CS-W001157 4
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1-Ethyl-1H-pyrazole-5-carboxylic acid

  • CAS No. 400755-43-3

  • Cat. No. CS-0130158
  • Purity≥97%
  • MDL No.MFCD02090833

*For research and further manufacturing use only, not for direct human use.

1-Ethyl-1H-pyrazole-5-carboxylic acid|CS-0130158

Structure of 400755-43-3

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General Information

  • CAS No. 400755-43-3
  • Cat. No. CS-0130158
  • Purity ≥97%
  • MDL No. MFCD02090833
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₂
  • Molecular Weight 140.14
  • Synonym(s) 1H-Pyrazole-5-carboxylicacid,1-ethyl-(9CI)
  • SMILES O=C(C1=CC=NN1CC)O

Description

1-Ethyl-1H-pyrazole-5-carboxylic acid features a pyrazole core with complementary electron-rich and carboxylic acid functionalities, enabling direct integration into bioconjugation and medicinal chemistry scaffolds. The ethyl substituent enhances solubility and metabolic stability in aqueous systems, while the para-carboxylic acid group provides a reactive handle for amide coupling or derivatization under standard conditions.

Application

1-Ethyl-1H-pyrazole-5-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrazole-based scaffolds in medicinal chemistry and agrochemical development. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions under standard conditions. The ethyl group enhances solubility and metabolic stability, while the pyrazole core provides robust structural rigidity and hydrogen-bonding capacity. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring functional group tolerance and predictable reactivity.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.6012
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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