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N-(Pyridin-2-yl)prop-2-enamide

  • CAS No. 40000-69-9

  • Cat. No. CS-0162721
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-(Pyridin-2-yl)prop-2-enamide|CS-0162721

Structure of 40000-69-9

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General Information

  • CAS No. 40000-69-9
  • Cat. No. CS-0162721
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) N-(pyridin-2-yl)acrylamide
  • SMILES C=CC(NC1=NC=CC=C1)=O

Description

N-(Pyridin-2-yl)prop-2-enamide features a conjugated enamide system linked to a pyridine ring, enabling strong π-interactions in coordination chemistry. This electron-deficient amide integrates readily into heterocyclic scaffolds and serves as a modular building block for ligands and bioactive molecules under standard conditions.

Application

N-(Pyridin-2-yl)prop-2-enamide serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles and conjugated systems. Its enamide functionality supports reliable Michael additions, cycloadditions, and transition-metal-catalyzed coupling reactions. The pyridyl moiety enhances solubility and provides a handle for further derivatization, while the α,β-unsaturated amide exhibits good bench stability and ease of purification—making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      504-29-0
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      814-68-6
    • ~70%
    • In-stock
      N-(Pyridin-2-yl)prop-2-enamide|CS-0162721
      40000-69-9

    References

    • Eriksson, Jonas; Aberg, Ola; Langstroem, Bengt European Journal of Organic Chemistry, 2007 , # 3 p. 455 - 461

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.2061
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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