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CS-W001157 4
Total: USD 88.00

3,6-Dibromo-2-methylpyridine

  • CAS No. 39919-65-8

  • Cat. No. CS-W003282
  • Purity≥97%
  • MDL No.MFCD06254589

*For research and further manufacturing use only, not for direct human use.

3,6-Dibromo-2-methylpyridine|CS-W003282

Structure of 39919-65-8

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General Information

  • CAS No. 39919-65-8
  • Cat. No. CS-W003282
  • Purity ≥97%
  • MDL No. MFCD06254589
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Br₂N
  • Molecular Weight 250.92
  • Synonym(s) None
  • SMILES CC1=C(Br)C=CC(Br)=N1

Description

3,6-Dibromo-2-methylpyridine features a pyridine core substituted with bromine atoms at positions 3 and 6 and a methyl group at position 2. This electron-deficient heterocycle serves as a key building block in transition metal-catalyzed cross-coupling reactions, offering enhanced reactivity and selectivity in the synthesis of functionalized aryl systems.

Application

3,6-Dibromo-2-methylpyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds via cross-coupling reactions. The bromine atoms facilitate palladium-catalyzed transformations, while the methyl group provides a site for selective functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • ANORMED INC. Patent: WO2007/22371 A2, 2007 ; Location in patent: Page/Page column 50-51 ; WO 2007/022371 A2
  • Route2
    • null|null
      853569-71-8
    • ~77%
    • In-stock
      3,6-Dibromo-2-methylpyridine|CS-W003282
      39919-65-8

    References

    • BRISTOL-MYERS SQUIBB PHARMA COMPANY Patent: WO2005/51954 A2, 2005 ; Location in patent: Page/Page column 38; 39 ; WO 2005/051954 A2
  • Route3
    • In-stock
      2-Amino-5-bromo-6-methylpyridine|CS-W007550
      42753-71-9
    • null|null
      853569-71-8
    • ~70%
    • In-stock
      3,6-Dibromo-2-methylpyridine|CS-W003282
      39919-65-8

    References

    • BRISTOL-MYERS SQUIBB PHARMA COMPANY Patent: WO2005/51954 A2, 2005 ; Location in patent: Page/Page column 38; 39 ; WO 2005/051954 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.91502
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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