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Structure of 399-44-0
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This difluorophenoxyacetic acid features a strategically positioned electron-withdrawing fluorine substitution pattern that enhances metabolic stability and lipophilicity. The ortho-fluoro groups influence conformational rigidity and improve binding affinity in bioactive scaffolds. Ideal for medicinal chemistry applications requiring enhanced membrane permeability and resistance to oxidative degradation.
(2,4-Difluorophenoxy)acetic acid serves as a versatile building block in medicinal and agrochemical synthesis, enabling the construction of bioactive heterocycles and functionalized aromatic systems. Its difluorophenyl ether moiety provides enhanced metabolic stability and membrane permeability, while the carboxylic acid group facilitates straightforward derivatization via esterification, amide coupling, or salt formation. The compound exhibits excellent bench stability and is compatible with standard synthetic protocols, making it a reliable component in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: