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CS-W001157 4
Total: USD 88.00

2-Amino-5-bromobenzophenone

  • CAS No. 39859-36-4

  • Cat. No. CS-0127705
  • Molecule weight276.13
  • Purity≥98%
  • MDL No.MFCD00059962

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-bromobenzophenone|CS-0127705

Structure of 39859-36-4

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General Information

  • CAS No. 39859-36-4
  • Cat. No. CS-0127705
  • Purity ≥98%
  • MDL No. MFCD00059962
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀BrNO
  • Molecular Weight 276.13
  • Synonym(s) 2-Benzoyl-4-bromoaniline
  • SMILES O=C(C1=CC(Br)=CC=C1N)C2=CC=CC=C2

Description

Diphenyl selenide is used for anti-selective Michael addition of thiols and their analogs to nitro-olefins.

Application

2-Amino-5-bromobenzophenone serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its compatible bromo and amino functionalities. The ortho-amino group facilitates directed metalation, while the aryl bromide supports reliable coupling with boronic acids, esters, and other nucleophiles. Its stability under standard reaction conditions and ease of purification make it well-suited for constructing complex heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1
    • 2-Aminobenzophenone Nepafenac Impurity|CS-0229200
      2835-77-0
    • ~95%
    • In-stock
      2-Amino-5-bromobenzophenone|CS-0127705
      39859-36-4

    References

    • Malherbe, Parichehr; Masciadri, Raffaello; Norcross, Roger David; Ratni, Hasane; Thomas, Andrew William Patent: US2006/94754 A1, 2006 ; Location in patent: Page/Page column 11 ; US 20060094754 A1
  • Route2

    References

    • Boruah, Monalisa; Konwar, Dilip Journal of Chemical Research - Part S, 2002 , # 12 p. 601 - 603
  • Route3
    • 2-Amino-5-bromo-N-methoxy-N-methylbenzamide|CS-0450775
      304854-54-4
    • null|null
      100-58-3
    • ~58%
    • In-stock
      2-Amino-5-bromobenzophenone|CS-0127705
      39859-36-4

    References

    • Maezaki, Hironobu; Banno, Yoshihiro; Miyamoto, Yasufumi; Moritou, Yuusuke; Asakawa, Tomoko; Kataoka, Osamu; Takeuchi, Koji; Suzuki, Nobuhiro; Ikedo, Koji; Kosaka, Takuo; Sasaki, Masako; Tsubotani, Shigetoshi; Tani, Akiyoshi; Funami, Miyuki; Yamamoto, Yoshio; Tawada, Michiko; Aertgeerts, Kathleen; Yano, Jason; Oi, Satoru Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 15 p. 4482 - 4498

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   3.2623
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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