Lot numbers can be found on the outside label of a product:
4-(Trifluoromethyl)-1,1'-biphenyl
-
CAS No. 398-36-7
- Cat. No. CS-0077600
- Purity≥97%
- MDL No.MFCD03412287
*For research and further manufacturing use only, not for direct human use.
Structure of 398-36-7
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 398-36-7
- Cat. No. CS-0077600
- Purity ≥97%
- MDL No. MFCD03412287
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₉F₃
- Molecular Weight 222.21
- Synonym(s) 4-(Trifluoromethyl)biphenyl
- SMILES FC(F)(F)C(C=C1)=CC=C1C2=CC=CC=C2
Description
4-(Trifluoromethyl)-1,1'-biphenyl features a trifluoromethyl group appended to a biphenyl scaffold, delivering enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables robust integration into pharmaceutical intermediates and functional materials, particularly where halogenated aromatic systems are required.
Application
4-(Trifluoromethyl)-1,1'-biphenyl serves as a valuable building block in the synthesis of functionalized biaryls and pharmaceutical intermediates. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the biphenyl core enables robust coupling reactions via Suzuki-Miyaura and Stille protocols. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for scale-up in medicinal chemistry campaigns.
Synthesis
-
Route1
-
108-86-1 -
In-stock
128796-39-4 - ~99%
-
In-stock
398-36-7
References
-
He, Ying; Cai, Chun Catalysis Letters, 2010 , vol. 140, # 3-4 p. 153 - 159
-
-
References
-
Li, Jin-Heng; Liu, Wen-Jie Organic Letters, 2004 , vol. 6, # 16 p. 2809 - 2811
-
-
Route3
-
853955-69-8 -
In-stock
455-13-0 - ~96%
-
In-stock
398-36-7
References
-
Nakao, Yoshiaki; Hiyama, Tamejiro Patent: US2009/69577 A1, 2009 ; Location in patent: Page/Page column 20 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 0
- LogP 4.3724
- H_Acceptors 0
- H_Donors 0
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 4-(Trifluoromethyl)-1,1'-biphenyl sigma4-(Trifluoromethyl)-1,1'-biphenyl manufacturer4-(Trifluoromethyl)-1,1'-biphenyl price4-(Trifluoromethyl)-1,1'-biphenyl structure4-(Trifluoromethyl)-1,1'-biphenyl SDSbuy 4-(Trifluoromethyl)-1,1'-biphenyl4-(Trifluoromethyl)-1,1'-biphenyl supplier4-(Trifluoromethyl)-1,1'-biphenyl uses4-(Trifluoromethyl)-1,1'-biphenyl molecular weightprice of 4-(Trifluoromethyl)-1,1'-biphenyl4-(Trifluoromethyl)-1,1'-biphenyl chemical name formula of 4-(Trifluoromethyl)-1,1'-biphenyl