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Structure of 39520-24-6
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Dimethyl 2-isobutylmalonate features a sterically hindered isobutyl group flanking a malonate core, enhancing its stability and enabling selective alkylation under mild conditions. This bench-stable diester integrates readily into synthetic sequences requiring controlled C–C bond formation, particularly in the construction of complex carboxylic acid derivatives and cyclic frameworks.
Dimethyl 2-isobutylmalonate serves as a versatile synthon in synthetic organic chemistry, enabling efficient construction of substituted cyclohexanones and other carbocyclic frameworks via Robinson annulation. Its malonate functionality exhibits high reactivity in alkylation and condensation reactions, while the isobutyl group provides steric differentiation and enhanced stability under standard reaction conditions. The compound facilitates straightforward purification and demonstrates broad functional group tolerance, making it a practical choice for iterative synthesis campaigns in medicinal chemistry and natural product synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: