Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-(Bromomethyl)-2-(trifluoromethyl)benzene

  • CAS No. 395-44-8

  • Cat. No. CS-W010300
  • Purity≥98%
  • MDL No.MFCD00013558

*For research and further manufacturing use only, not for direct human use.

1-(Bromomethyl)-2-(trifluoromethyl)benzene|CS-W010300

Structure of 395-44-8

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 395-44-8
  • Cat. No. CS-W010300
  • Purity ≥98%
  • MDL No. MFCD00013558
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrF₃
  • Molecular Weight 239.03
  • Synonym(s) α-Bromo-α',α',α'-trifluoro-o-xylene
  • SMILES FC(C1=CC=CC=C1CBr)(F)F

Description

1-(Bromomethyl)-2-(trifluoromethyl)benzene features a bromomethyl group flanked by a strongly electron-withdrawing trifluoromethyl substituent, enabling efficient cross-coupling reactions. This aryl halide exhibits enhanced reactivity in palladium-catalyzed transformations due to the combined electronic effects of the CF₃ and Br functionalities, facilitating the construction of complex biaryl architectures under standard conditions.

Application

1-(Bromomethyl)-2-(trifluoromethyl)benzene serves as a versatile aryl halide building block for C–C coupling reactions, enabling efficient construction of biaryl and heterocyclic scaffolds. The bromomethyl group exhibits high reactivity in palladium-catalyzed cross-couplings, while the ortho-trifluoromethyl substituent imparts enhanced metabolic stability and modulates electronic properties. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Filler,R.; Novar,H. Journal of Organic Chemistry, 1960 , vol. 25, p. 733 - 736
  • Route2

    References

    • Short,J.H.; Biermacher,U. Journal of Pharmaceutical Sciences, 1962 , vol. 51, p. 881 - 884
  • Route3
    • null|null
      3796-19-8
    • ~%
    • In-stock
      1-(Bromomethyl)-2-(trifluoromethyl)benzene|CS-W010300
      395-44-8

    References

    • Filler,R.; Novar,H. Journal of Organic Chemistry, 1960 , vol. 25, p. 733 - 736

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   0
  • LogP   3.6003
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 395-44-8 sigma395-44-8 manufacturer395-44-8 price395-44-8 structure395-44-8 SDSbuy 395-44-8395-44-8 supplier395-44-8 uses395-44-8 molecular weightprice of 395-44-8395-44-8 chemical name formula of 395-44-8
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label