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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methoxybenzoic acid

  • CAS No. 394-42-3

  • Cat. No. CS-W002640
  • Purity≥98%
  • MDL No.MFCD00509373

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methoxybenzoic acid|CS-W002640

Structure of 394-42-3

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General Information

  • CAS No. 394-42-3
  • Cat. No. CS-W002640
  • Purity ≥98%
  • MDL No. MFCD00509373
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃
  • Molecular Weight 170.14
  • Synonym(s) 2-Fluoro-p-anisic Acid
  • SMILES O=C(O)C1=CC=C(OC)C=C1F

Description

2-Fluoro-4-methoxybenzoic acid delivers a strategically positioned fluorine atom and methoxy group that enhance metabolic stability and lipophilicity in bioactive molecule design. This electron-withdrawing combination improves binding affinity in kinase inhibitors and other pharmaceutical scaffolds. The carboxylic acid functionality enables direct coupling or derivatization under standard amide formation conditions.

Application

2-Fluoro-4-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard esterification, amide coupling, or Suzuki-Miyaura cross-coupling reactions. Its orthogonal functional groups—fluorine for metabolic stability and methoxy for electronic modulation—facilitate fine-tuning of physicochemical properties. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.5325
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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