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Structure of 391211-97-5
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This difluorinated benzoic acid features a fluorinated aniline moiety that enhances electron withdrawal and metabolic stability. The para-iodo substituent enables facile cross-coupling transformations, while the ortho-fluoro group modulates reactivity and solubility. Designed for late-stage functionalization in medicinal chemistry, this scaffold integrates readily into bioactive molecules under standard coupling conditions.
3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid serves as a versatile building block for constructing bioactive heterocycles and pharmaceutical scaffolds. Its ortho-difluorinated aryl core enables efficient cross-coupling reactions, while the iodo and amino functionalities provide orthogonal handles for Pd-catalyzed transformations. The carboxylic acid group facilitates derivatization and purification via standard chromatographic or crystallization methods. This compound exhibits bench stability and functional group compatibility, making it well-suited for iterative synthesis in medicinal chemistry campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: