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Structure of 391-78-6
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6-Fluoroquinolin-4-ol features a fluorine atom at the 6-position of the quinoline core, enhancing electron-withdrawing character and modulating reactivity. The phenolic hydroxyl group enables hydrogen bonding and facilitates derivatization. This scaffold combines planarity with tunable polarity, supporting applications in medicinal chemistry and materials science.
6-Fluoroquinolin-4-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 hydroxyl and C6 fluorine positions. Its stability under standard reaction conditions facilitates nucleophilic substitution, palladium-catalyzed coupling, and derivatization for heterocyclic scaffolds. The molecule functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive compounds, offering predictable reactivity and ease of purification in multi-step sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: