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CS-W001157 4
Total: USD 88.00

N,N-Dimethylmorpholine-4-carboxamide

  • CAS No. 38952-61-3

  • Cat. No. CS-0151343
  • Molecule weight158.20
  • Purity≥98%
  • MDL No.MFCD02859873

*For research and further manufacturing use only, not for direct human use.

N,N-Dimethylmorpholine-4-carboxamide|CS-0151343

Structure of 38952-61-3

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General Information

  • CAS No. 38952-61-3
  • Cat. No. CS-0151343
  • Purity ≥98%
  • MDL No. MFCD02859873
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄N₂O₂
  • Molecular Weight 158.20
  • Synonym(s) 4-Morpholinecarboxamide, N,N-dimethyl
  • SMILES CN(C)C(=O)N1CCOCC1

Description

N,N-Dimethylmorpholine-4-carboxamide features a morpholine ring with a dimethylamino group and a carboxamide handle, offering enhanced solubility and stability in polar reaction media. This combination enables efficient coupling in peptide synthesis and facilitates conjugation workflows under standard conditions.

Application

N,N-Dimethylmorpholine-4-carboxamide serves as a versatile amide building block in synthetic organic chemistry, offering enhanced solubility and stability compared to conventional amides. Its morpholine scaffold provides favorable polarity and metabolic resistance, making it valuable in medicinal chemistry for constructing bioactive heterocycles. The N,N-dimethyl substitution enhances lipophilicity and reduces hydrogen bonding potential, facilitating purification and enabling compatibility with diverse coupling reactions.

Synthesis

  • Route1
    • null|null
      110-91-8
    • null|null
      79-44-7
    • ~92%
    • In-stock
      N,N-Dimethylmorpholine-4-carboxamide|CS-0151343
      38952-61-3

    References

    • El-Faham, Ayman; Albericio, Fernando Journal of Peptide Science, 2010 , vol. 16, # 1 p. 6 - 9
  • Route2
    • null|null
      110-91-8
    • ~91%
    • In-stock
      N,N-Dimethylmorpholine-4-carboxamide|CS-0151343
      38952-61-3

    References

    • LUXEMBOURG BIO TECHNOLOGIES LTD. Patent: US2010/144588 A1, 2010 ;
  • Route3
    • null|null
      110-91-8
    • null|null
      68-12-2
    • ~32%
    • In-stock
      N,N-Dimethylmorpholine-4-carboxamide|CS-0151343
      38952-61-3

    References

    • Kumar, G. Sathish; Kumar, R. Arun; Kumar, P. Santhosh; Reddy, N. Veera; Kumar, K. Vijaya; Kantam, M. Lakshmi; Prabhakar; Reddy, K. Rajender Chemical Communications, 2013 , vol. 49, # 59 p. 6686 - 6688

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.78
  • LogP   0.0002
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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