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CS-W001157 4
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Fmoc-D-Dab(Aloc)-OH

  • CAS No. 387824-78-4

  • Cat. No. CS-0157978
  • Purity≥97%
  • MDL No.MFCD02094487

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Dab(Aloc)-OH|CS-0157978

Structure of 387824-78-4

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General Information

  • CAS No. 387824-78-4
  • Cat. No. CS-0157978
  • Purity ≥97%
  • MDL No. MFCD02094487
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₄N₂O₆
  • Molecular Weight 424.45
  • Synonym(s) Butanoicacid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[[(2-propenyloxy)carbonyl]amino]-,(2R)-
  • SMILES C=CCOC(NCC[C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C(O)=O)=O

Description

Fmoc-D-Dab(Aloc)-OH is a protected diaminobutyric acid derivative featuring a fluorenylmethyloxycarbonyl group at the N-terminus and an allyloxycarbonyl group on the side chain amine. This bifunctional protection enables orthogonal deprotection in peptide synthesis, allowing selective manipulation of the side chain while preserving backbone integrity. The compound exhibits excellent solubility in common organic solvents and stability under standard handling conditions, facilitating efficient incorporation into complex peptide sequences.

Application

Fmoc-D-Dab(Aloc)-OH serves as a key building block for the synthesis of peptide-based therapeutics, enabling site-specific incorporation of D-lysine derivatives with orthogonal protection. The Aloc group provides reliable, acid-labile deprotection compatible with standard Fmoc-SPPS workflows, while the Fmoc moiety ensures efficient coupling and traceless removal. This derivative offers enhanced solubility and purification ease in solid-phase synthesis, facilitating the construction of complex cyclic peptides and macrocyclic scaffolds relevant to drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   113.96
  • LogP   3.2806
  • H_Acceptors   5
  • H_Donors   3
  • Rotatable_Bonds   9

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