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CS-W001157 4
Total: USD 88.00

6-Bromochroman

  • CAS No. 3875-78-3

  • Cat. No. CS-M3131
  • Purity≥95%
  • MDL No.MFCD10698725

*For research and further manufacturing use only, not for direct human use.

6-Bromochroman|CS-M3131

Structure of 3875-78-3

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General Information

  • CAS No. 3875-78-3
  • Cat. No. CS-M3131
  • Purity ≥95%
  • MDL No. MFCD10698725
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉BrO
  • Molecular Weight 213.07
  • Synonym(s) Chroman, 6-bromo-; 6-BROMO-CHROMAN
  • SMILES BrC1=CC(CCCO2)=C2C=C1

Description

6-Bromochroman delivers a versatile brominated chroman scaffold for synthetic transformations. This bench-stable, moisture-tolerant compound features a reactive bromine at the 6-position, enabling palladium-catalyzed cross-coupling reactions. The electron-deficient aromatic ring facilitates nucleophilic substitution, while the fused oxygen heterocycle provides structural rigidity and enhanced solubility in organic solvents. Ideal for medicinal chemistry and materials synthesis workflows.

Application

6-Bromochroman serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo substituent. The chroman scaffold provides a rigid, oxygen-containing heterocyclic framework with established utility in medicinal chemistry and materials science. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient functionalization for downstream applications.

Synthesis

  • Route1

    References

    • Kelley, Charles J.; Ghiorghis, Alem; Kauffman, Joel M. Journal of Chemical Research, Miniprint, 1997 , # 12 p. 2701 - 2733
  • Route2
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      106-41-2
    • ~%
    • In-stock
      6-Bromochroman|CS-M3131
      3875-78-3

    References

    • Yang, Geng-Liang; Song, Ya-Li; Liu, Xiao-Ming; Yang, Ning Asian Journal of Chemistry, 2013 , vol. 25, # 4 p. 1849 - 1852
  • Route3
    • 3-(4-Bromophenoxy)propan-1-ol|CS-0669917
      67900-64-5
    • ~%
    • In-stock
      6-Bromochroman|CS-M3131
      3875-78-3

    References

    • Chatelus Annales de Chimie (Cachan, France), 1949 , vol. <12> 4, p. 505,526

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.7741
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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