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CS-W001157 4
Total: USD 88.00

2-(Methylsulfonyl)thiophene

  • CAS No. 38695-60-2

  • Cat. No. CS-0053912
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Methylsulfonyl)thiophene|CS-0053912

Structure of 38695-60-2

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General Information

  • CAS No. 38695-60-2
  • Cat. No. CS-0053912
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆O₂S₂
  • Molecular Weight 162.23
  • Synonym(s) 2-Methylsulfonylthiophene
  • SMILES O=S(C1=CC=CS1)(C)=O

Description

2-(Methylsulfonyl)thiophene features a thiophene core functionalized with a methylsulfonyl group, delivering enhanced polarity and metabolic stability. This electron-withdrawing substituent improves solubility and facilitates downstream derivatization in medicinal chemistry campaigns. The compound exhibits bench-stable handling characteristics and serves as a valuable scaffold for bioactive molecule design.

Application

2-(Methylsulfonyl)thiophene serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to functionalized thiophene scaffolds. The methylsulfonyl group enhances solubility and metabolic stability while tolerating a range of reaction conditions. It functions effectively in cross-coupling reactions and acts as a reliable handle for further derivatization, offering robust bench stability and straightforward purification—ideal for iterative synthesis campaigns in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.1516
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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